I posted a few bugs in a previous thread -
http://www.zionworx.org.uk/forum/viewtopic.php?t=618.
These were all tested on Vista Home Basis and not Business, and today I retested them on Business Edition and only the last one in the list was not repeatable (maybe its a Home Basic "feature" or the video device driver I am using has been updated since November).
--Correction to the above comment - it is dependant upon where you position the second monitor. If the monitor is to the right of the management screen it works fine, anywhere else (or if you only have one monitor enabled) then you cannot restore the application without the use of the right-click mouse button.
--End of edit to post
The big issue is still the fact that the product stores its settings in ini files in Program Files directory - Vista does not like that - try logging in as a different user on the same machine and see what happens to your database and all your styles etc.