Are you using a projector as your secondary output? If so, you may be trying to drive the projector at a resolution which is too high for it to support.
To work out what the problem is, I suggest you ditch the projector and just plug another standard monitor into the second video output. Then close ZionWorx and change the resolution of both monitors to 800x600 in Display Properties->Settings. Like Edd says, also make sure that the 2 monitor images are aligned the same too. Then restart ZionWorx and see how it looks. If it works, then try swapping the monitor for the projector.
You should also try assigning an image to the desktop background and check that it displays correctly on both monitors.
The problem will no doubt turn out to be something simple so don't give up